System Requirements for ChemDraw and Signals ChemDraw
The tabs below list the system requirements for the current and older versions of the ChemDraw product family:
- Operating Systems: Specifications for Windows and macOS
- Hardware: Requirements for processor, RAM, and hard disk space
- Integration with Office applications and other software: Compatibility with Microsoft Office, .NET Framework, and browsers
Version 25
System Requirements for ChemDraw ChemDraw 25 and Signals ChemDraw 25
Hardware Requirements
- Memory (RAM): 64-bit OS: Minimum 2 GB, Recommended 3 GB
- Processor: Minimum 1.6 GHz or higher, Recommended 3.0 GHz or higher dual-core processor
- Free Space Required on Hard Drive:
- Minimum 1 GB - 4 GB (4 GB is for installing the full ChemOffice Professional version.) This is for installation only and does not include any creation/expansion of any databases.
- 10 GB recommended specification
- Screen resolution: 1024 x 768 or higher recommended specification
Software Requirements
Windows
- Windows 10, 11 (64 bit)
- Microsoft Office 2021 (32 and 64 bit), Microsoft Office 2024 (64 bit) (Note: The latest update used for testing is version 2503 (Build 16.0.18623.20266).)
- .NET-Framework 4.8
Macintosh
- macOS 15.5 (Sequoia), macOS Tahoe (26.0.1) – (ChemDraw only)
- Microsoft Office 2021, 2024, or Office 365, 32 bit only (Note: The latest update used for testing is 16.97 (2501114).)
Version 23
System Requirements for ChemDraw 23 and Signals ChemDraw 23
Hardware Requirements
- Memory (RAM):64-bit OS: Minimum 2 GB, Recommended 3 GB
- Processor: Minimum 1.6 GHz or higher, Recommended 3.0 GHz or higher dual-core processor
- Free Space Required on Hard Drive:
- Minimum 1 GB - 4 GB (4 GB is for installing the full ChemOffice Professional version.) This is for installation only and does not include any creation/expansion of any databases.
- 10 GB recommended specification
- Screen Resolution: 1024 x 768 or higher recommended specification
Software Requirements
Windows
- Windows 10, 11 (64-Bit)
- Microsoft Office 2019 (32-bit and 64-bit), Microsoft Office 2021 (32-bit and 64-bit), Office 365 (32-bit and 64-bit) (Note: The latest update used for testing is 2312 (Build 16.0.17216.20132).)
- .NET-Framework 4.8
- Microsoft Edge in Internet Explorer (IE) mode for ActiveX controls in the browser
Macintosh
- macOS 13.6 (Ventura) or 14.2 (Sonoma) – (ChemDraw Prime and Professional only)
- Microsoft Office 2019, 2021 or Office 365 (32 bit only) (Note: The latest update used for testing is 16.81 (24011402).)
- Adobe Acrobat DC
Version 22
System Requirements for ChemDraw 22 and ChemOffice 22
Hardware Requirements
- Memory (RAM):64 bit OS: 2 GB recommended specification
- Processor: Minimum 1.6 GHz or higher, Recommend 3.0 GHz or higher dual-core processor
- Free Space Required on Hard Drive:
- Minimum 300 MB - 1 GB (1 GB is for installing the full ChemOffice Professional version.) This is for installation only and does not include any creation/expansion of any databases.
- 10 GB recommended specification
- Screen Resolution: 1024 x 768 or higher recommended specification
Software Requirements
Windows
- Windows 10, 11 (64 bit)
- Microsoft Office 2019 (32-bit and 64-bit), Microsoft Office 2021 (32-bit and 64-bit), Office 365 (32-bit and 64-bit) (Note: The latest update used for testing is 2208 (Build 16.0.15601.20078).)
- .NET-Framework 4.8
- Microsoft Edge in Internet Explorer (IE) mode for ActiveX controls in the browser
Macintosh
- macOS 11.6 (Big Sur), macOS 12.5 (Monterey) or 13.0 (Ventura) – (ChemDraw Prime and Professional only)
- Microsoft Office 2019, 2021, or Office 365 (32 bit only) (Note: The latest update used for testing is 16.64 (22081401).)
Version 21
System Requirements for ChemDraw 21 and ChemOffice 21
Hardware Requirements
- Memory (RAM):
- 32 bit OS: 1 GB recommended specification
- 64 bit OS: 2 GB recommended specification
- Processor: Minimum 1.6 GHz or higher, Recommend 3.0 GHz or higher dual-core processor
- Free Space Required on Hard Drive:
- Minimum 300 MB - 1 GB (1GB is for installing the full ChemOffice Professional version.) This is for installation only and does not include any creation/expansion of any databases.
- 10 GB recommended specification
- Screen Resolution: 1024 x 768 or higher recommended specification
Software Requirements
Windows
- Windows 10, 11 (64 bit)
- Microsoft Office 2019 (32-bit and 64-bit), Microsoft Office 2021 (32-bit and 64-bit), Office 365 (32-bit and 64-bit) (Note: The latest update used for testing is 2008 (13127.20408).)
- .NET-Framework 4.x
- Microsoft Edge in Internet Explorer (IE) mode for ActiveX controls in the browser
Macintosh
- macOS 11.6 (Big Sur) or macOS 12.1 (Monterey) – (ChemDraw Prime and Professional only)
- Microsoft Office 2019, Microsoft Office 2021, Office 365 (32 bit only) (Note: The latest update used for testing is 16.41 (20091302).)