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ADME DB

ADME DB is a database containing the latest and most comprehensive data on interactions of substances with Drug Metabolizing Enzymes and Drug Transporters. It is designed for use in drug research and development, including drug-drug interactions and ADME (Absorption, Distribution, Metabolism and Excretion) studies. The information is organized by category (therapeutic area), drug name, enzyme, reaction, and type. ADME DB is supported by chemical/metabolite structures as well as kinetic values found in the literature. The database is available online and completely searchable by keywords or chemical structures. Advanced searches are also available to support investigational studies on drug-drug interactions. The contents of the database were collected and organized in accordance with the original Human CYP and Transporter Metabolism Database as developed by Professor Slobodan Rendic (Zagreb, Croatia).

ADME DB

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Datenbankstruktur

Datenbankstruktur

ADMEDB contains information on CYP and other Phase I and Phase II enzymes and a number of variants, which significantly contribute/are tested in the metabolism of xenobiotics (drugs and other chemicals) and endobiotics in humans in vitro and in vivo.

ADMEBD contains three sub-databases:

Detailed information for each entry includes the following data items:

Human Drug Metabolizing Enzymes Database

Cytochrome P450

Kinetic Metabolism Database

Database contains over 26 000 entries extracted from Human Cytochrome P450 metabolism database references providing numerical data on major kinetic parameters relevant for use in drug developing/application studies.

Kinetic Inforamtion

Transportesr Database

Einsatzbereiche

Einsatzbereiche

Vorteile

Vorteile

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